2. Academic Validation
  3. Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity

  • Evid Based Complement Alternat Med. 2022 Nov 21:2022:9315318. doi: 10.1155/2022/9315318.
Yue Wang 1,  Ying Han 2 3,  Rongfu Lv 4,  Chengyong He 1,  Zhenghong Zuo 1,  Ying Chen 1,  Jiyi Huang 1
Affiliations

Affiliations

  • 1 Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, The First Affiliated Hospital of Xiamen University, School of Medicine, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.
  • 2 The Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361101, Fujian, China.
  • 3 Xiamen Key Laboratory of Genetic Testing, Xiamen 361101, Fujian, China.
  • 4 Xiamen Herbt Biotechnology Company Limited, Xiamen, Fujian 361005, China.
PMID: 39280956 DOI: 10.1155/2022/9315318
Abstract

Tea is one of the most popular beverages in the world. The health-promoting effects of tea and its individual constituents, including antiobesity and antihyperlipidaemia effects, have been well accepted. In this study, we evaluated the effects of herbal tea essence (HTE), a commercial product extracted from black tea, on HFD-induced obesity in mice. HTE effectively reduces the gain in body weight and improves glucose tolerance and Insulin sensitivity after HFD treatment. HTE inhibits lipid accumulation in the body and reduces serum lipid contents. Furthermore, HTE negatively regulates the expression levels of genes that control lipogenesis and gluconeogenesis and upregulates the expression of genes for lipid β oxidation. The regulatory effects of HTE on these genes may occur through activation of the Akt, IRS-1, and AMPK signalling pathways. Our observations suggest that HTE could be a promising option for nutritional intervention in the treatment of obesity.

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