2. Academic Validation
  3. Targeting tumor metabolic flexibility enhances radiotherapeutic efficacy via mitochondrial complex I Inhibition in an intracranial S180 sarcoma mouse model

Targeting tumor metabolic flexibility enhances radiotherapeutic efficacy via mitochondrial complex I Inhibition in an intracranial S180 sarcoma mouse model

  • Sci Rep. 2025 Nov 28. doi: 10.1038/s41598-025-29326-2.
Zhipeng Liu 1 2,  Sa-Hoe Lim 2 3 4,  Shin Jung 5 6 7
Affiliations

Affiliations

  • 1 Department of Neurosurgery, Ningbo Second Hospital, Ningbo, Zhejiang, China.
  • 2 Brain Tumor Research Laboratory, Biomedical Research Institute, Chonnam National University Hwasun Hospital, Gwangju, 58128, Republic of Korea.
  • 3 Department of Neurosurgery, Chonnam National University Medical School, Hwasun Hospital, 322 Seoyang-ro, Gwangju, 58128, Republic of Korea.
  • 4 Department of Neurosurgery, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, 58128, Republic of Korea.
  • 5 Brain Tumor Research Laboratory, Biomedical Research Institute, Chonnam National University Hwasun Hospital, Gwangju, 58128, Republic of Korea. [email protected].
  • 6 Department of Neurosurgery, Chonnam National University Medical School, Hwasun Hospital, 322 Seoyang-ro, Gwangju, 58128, Republic of Korea. [email protected].
  • 7 Department of Neurosurgery, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, 58128, Republic of Korea. [email protected].
PMID: 41310084 DOI: 10.1038/s41598-025-29326-2
Keywords

ATP synthesis; Apoptosis; Mitochondrial dysfunction; Radiation; Reactive oxygen species; Sarcoma.

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