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IACS-10759 Hydrochloride 

Cat. No.: HY-112037A Purity: 98.91%
Handling Instructions

IACS-10759 Hydrochloride is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

For research use only. We do not sell to patients.

IACS-10759 Hydrochloride Chemical Structure

IACS-10759 Hydrochloride Chemical Structure

CAS No. : 1807523-99-4

Size Price Stock Quantity
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of IACS-10759 Hydrochloride:

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Description

IACS-10759 Hydrochloride is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

IC50 & Target

OXPHOS[1]

In Vitro

IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1].

In Vivo

IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1].

Molecular Weight

599.02

Formula

C₂₅H₂₆ClF₃N₆O₄S

CAS No.

1807523-99-4

SMILES

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (166.94 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6694 mL 8.3470 mL 16.6939 mL
5 mM 0.3339 mL 1.6694 mL 3.3388 mL
10 mM 0.1669 mL 0.8347 mL 1.6694 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IACS-10759IACS10759IACS 10759OthersInhibitorinhibitorinhibit

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Product name:
IACS-10759 Hydrochloride
Cat. No.:
HY-112037A
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