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IACS-10759 

Cat. No.: HY-112037 Purity: 99.58%
Handling Instructions

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

For research use only. We do not sell to patients.

IACS-10759 Chemical Structure

IACS-10759 Chemical Structure

CAS No. : 1570496-34-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 186 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of IACS-10759:

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  • Biological Activity

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  • References

Description

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

IC50 & Target

OXPHOS[1]

In Vitro

IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1].

In Vivo

IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (111.10 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7776 mL 8.8879 mL 17.7759 mL
5 mM 0.3555 mL 1.7776 mL 3.5552 mL
10 mM 0.1778 mL 0.8888 mL 1.7776 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.70 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

562.56

Formula

C₂₅H₂₅F₃N₆O₄S

CAS No.

1570496-34-2

SMILES

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.58%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
IACS-10759
Cat. No.:
HY-112037
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IACS-10759

Cat. No.: HY-112037