Pterostilbene regulates circadian clock gene expression in high-fat diet-induced obese mice

Pterostilbene (PTE) has emerged as a metabolic regulator with anti-obesity properties. However, the precise mechanism underlying these anti-obesity effects remains unclear. Given that the circadian clock machinery controls various biological processes, including metabolism, it remains unclear whether PTE impedes obesity by influencing the circadian clock. In the current study, an obese mouse model was established using a high-fat diet induction method, and the obese mice were treated with PTE. PTE was found to effectively improve dysregulated blood glucose, Insulin, and lipid levels in obese mice. Moreover, PTE treatment mitigated lipid accumulation in the liver and peritesticular fat tissues of obese mice. Notably, qPCR results revealed that the disrupted phasic expression of circadian clock genes in obese mice was efficiently rescued by PTE consumption. These observations suggest that PTE partially inhibits obesity by normalizing the circadian clock. Our findings suggest a possible mechanism for the anti-obesity effect of PTE, highlighting its potential as a therapeutic agent to combat obesity.

Circadian clock; high-fat diet; insulin; nicotinamide; pterostilbene.