2. Academic Validation
  3. Metapanax delavayi extract as a neurocutaneous modulator via CRHR1/POMC/MC1R signaling

Metapanax delavayi extract as a neurocutaneous modulator via CRHR1/POMC/MC1R signaling

  • Sci Rep. 2026 Feb 9;16(1):7851. doi: 10.1038/s41598-026-39343-4.
Anming Zhu 1 2,  Junxi Liu 3 4,  Youyun Liu 1 2,  Rui Xu 1 2,  Yonglei Yuan 1 2,  Qiwen Sun 1 2,  Feifei Wang 1 5 2,  Liping Qu 6 7 8
Affiliations

Affiliations

  • 1 Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, 650106, China.
  • 2 Botanee Research Institute, Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, 201702, China.
  • 3 Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, 650106, China. [email protected].
  • 4 Botanee Research Institute, Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, 201702, China. [email protected].
  • 5 Yunnan Characteristic Plant Extraction Laboratory, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Kunming, 650106, China.
  • 6 Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, 650106, China. [email protected].
  • 7 Yunnan Characteristic Plant Extraction Laboratory, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Kunming, 650106, China. [email protected].
  • 8 Botanee Research Institute, Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, 201702, China. [email protected].
PMID: 41663512 DOI: 10.1038/s41598-026-39343-4
Abstract

Metapanax delavayi (Franch.) J. Wen & Frodin (Araliaceae) is a plant with both medicinal and edible value, but there is no study examining its effects on skin neurogenic inflammation. We investigated the anti-neurogenic inflammatory and soothing potential of Metapanax delavayi extract (MDE) in vitro using SH-SY5Y cells activated by capsaicin and HaCaT cells stimulated by substance P, and in vivo using a heat-induced zebrafish model. We found that MDE significantly inhibited TRPV1 activation and intracellular calcium influx, down-regulated neuropeptides (CGRP, NGF, substance P) and proinflammatory cytokines (IL-1α, IL-6, IL-8), and regulated emotion-related Hormones (decreased cortisol, increased β-endorphin). It also reduced heat-induced hypermotility in zebrafish. Critically, the mechanistic study suggests that biological activity may be associated with the inactivation of the CRHR1/POMC/MC1R signaling pathway. Collectively, these findings indicate that MDE possesses significant potential as a natural skincare ingredient for counteracting neurogenic inflammation associated with sensitive skin.

Keywords

Metapanax delavayi extract; Emotional skincare; Neuropeptides; Skin neurogenic inflammation; TRPV1.

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