2. Academic Validation
  3. A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis

A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis

  • J Nat Med. 2026 Mar 9. doi: 10.1007/s11418-025-01966-8.
Meng Lv 1 2 3,  Xiangrui Chen 4,  Yaqiong Wang 1 2 3,  Qiting Yang 5,  Yongbiao Lv 6,  Wei Xie 1 2 3,  Junxiang Cai 7
Affiliations

Affiliations

  • 1 Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, China.
  • 2 The Fourth Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 3 Shenzhen Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Shenzhen, China.
  • 4 Department of Hematology and Oncology, Third People's Hospital of Zigong, Zigong, China.
  • 5 Department of Cardiopulmonary Rehabilitation and Sleep Medicine, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 6 The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 7 Department of Respiratory and Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111, Dade Road, Guangzhou, 510120, China. [email protected].
PMID: 41801295 DOI: 10.1007/s11418-025-01966-8
Keywords

Lycorine; Non-small cell lung cancer; SPC25; ZNF143.

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