2. Academic Validation
  3. Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

  • Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. doi: 10.1016/s0960-894x(98)00252-2.
T R Belliotti 1,  W A Brink,  S R Kesten,  J R Rubin,  D J Wustrow,  K T Zoski,  S Z Whetzel,  A E Corbin,  T A Pugsley,  T G Heffner,  L D Wise
Affiliations

Affiliation

  • 1 Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.
PMID: 9873377 DOI: 10.1016/s0960-894x(98)00252-2
Abstract

PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.

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