1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. PD 168568 dihydrochloride

PD 168568 dihydrochloride 

Cat. No.: HY-103407A
Handling Instructions

PD 168568 dihydrochloride is an orally active and selective D4 dopamine receptor antagonist, with a Ki of 8.8 nM.

For research use only. We do not sell to patients.

PD 168568 dihydrochloride Chemical Structure

PD 168568 dihydrochloride Chemical Structure

CAS No. : 1782532-06-2

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Description

PD 168568 dihydrochloride is an orally active and selective D4 dopamine receptor antagonist, with a Ki of 8.8 nM[1].

IC50 & Target[1]

D4 Receptor

8.8 nM (Ki)

In Vitro

PD 168568 dihydrochloride has good selective for D4 receptor, with a Ki of 1842 nM for D2 receptor[1].

In Vivo

PD 168568 dihydrochloride has ability to inhibit amphetamine stimulated locomotor activity in the rat[1].

Animal Model: Rat[1]
Dosage: 3 mg/kg
Administration: Oral administration
Result: Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
Molecular Weight

422.39

Formula

C₂₂H₂₉Cl₂N₃O

CAS No.

1782532-06-2

SMILES

O=C1NC(CCN2CCN(C3=CC=C(C)C(C)=C3)CC2)C4=C1C=CC=C4.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PD 168568PD168568PD-168568Dopamine ReceptorD4schizophreniadopaminereceptorD2familyInhibitorinhibitorinhibit

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PD 168568 dihydrochloride
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HY-103407A
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