Isoindolinone enantiomers having affinity for the dopamine D4 receptor

  • Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. doi: 10.1016/s0960-894x(98)00252-2.
T R Belliotti  1 ,  W A Brink ,  S R Kesten ,  J R Rubin ,  D J Wustrow ,  K T Zoski ,  S Z Whetzel ,  A E Corbin ,  T A Pugsley ,  T G Heffner ,  L D Wise
Affiliations
  • 1. Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.
PMID: 9873377 DOI: 10.1016/s0960-894x(98)00252-2
Abstract

PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.

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