PD 168568

Cat. No.: HY-103407: FAQs
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PD 168568 is a orally active and potent dopamine receptor D₄ (DRD₄) antagonist. PD 168568 contains an isoindolinone and is selective for the D₄ receptor versus D₂ and D₃, with K_i values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research.

For research use only. We do not sell to patients.

PD 168568 Chemical Structure

CAS No. : 210688-56-5

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Other Forms of PD 168568:

PD 168568 dihydrochloride Get quote

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

D₄ Receptor

8.8 nM (Ki)

D₂ Receptor

1842 nM (Ki)

D₃ Receptor

2682 nM (Ki)

In Vitro

PD 168568 shows selectivity inhibition toward glioblastoma neural stem cells (GNS), with IC₅₀ of 25-50 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PD 168568 (3 mg/kg, Oral) has ability to inhibit amphetamine-stimulated locomotor activity in the rat^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat^[1]
Dosage:	3 mg/kg
Administration:	Oral administration
Result:	Inhibited amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.

Molecular Weight

349.47

Formula

C₂₂H₂₇N₃O

CAS No.

210688-56-5

SMILES

O=C1NC(CCN2CCN(C3=CC=C(C)C(C)=C3)CC2)C4=C1C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dolma S, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016 Jun 13;29(6):859-873. [Content Brief]

[2]. Lindsley CW, et al. Return of D4 Dopamine Receptor Antagonists in Drug Discovery. J Med Chem. 2017 Sep 14;60(17):7233-7243. [Content Brief]

[3]. Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. [Content Brief]

PD 168568 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 168568210688-56-5PD168568PD-168568Dopamine ReceptorPrimary GBM Tumor CellsGlioblastomaamphetamineInhibitorinhibitorinhibit

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