210688-56-5
210688-56-5
Chemical Structure
PD 168568
- CAS No.: 210688-56-5
- Formula:C22H27N3O
- Molecular Weight:349.47
IUPAC Name: 3-(2-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethyl)isoindolin-1-one
InChIKey: WQEPZBNLBWDIRZ-UHFFFAOYSA-N
SMILES: O=C1NC(CCN2CCN(C3=CC=C(C)C(C)=C3)CC2)C4=C1C=CC=C4
Biological Activity: PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research[1][2].
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PD 168568 | PD 168568 is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research. | |||||||||||||||||||||
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References
- [1]. Dolma S, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016 Jun 13;29(6):859-873. [Content Brief]
- [2]. Lindsley CW, et al. Return of D4 Dopamine Receptor Antagonists in Drug Discovery. J Med Chem. 2017 Sep 14;60(17):7233-7243. [Content Brief]
Keywords
