Me-Tet-PEG4-NH2 hydrochloride

Name: Me-Tet-PEG4-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-133505
Rating: 4.5 (0 reviews)

Cat. No.: HY-133505 Purity: 95.04%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Me-Tet-PEG4-NH2 hydrochloride 화학구조

CAS No. : 2656478-51-0

사이즈	재고	수량
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Me-Tet-PEG4-NH2 hydrochloride:

Me-Tet-PEG4-NH2 견적 받기

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•Related Small Molecules:

•Related Proteins:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

484.98

화학식

C₂₁H₃₃ClN₆O₅

CAS No.

2656478-51-0

Appearance

Oil

Color

Purple to purplish red

SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(CCOCCOCCOCCOCCN)=O.Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

Methanol : 125 mg/mL (257.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0619 mL	10.3097 mL	20.6194 mL
5 mM	0.4124 mL	2.0619 mL	4.1239 mL
10 mM	0.2062 mL	1.0310 mL	2.0619 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.04%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (242 KB) HNMR (270 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	2.0619 mL	10.3097 mL	20.6194 mL	51.5485 mL
	5 mM	0.4124 mL	2.0619 mL	4.1239 mL	10.3097 mL
	10 mM	0.2062 mL	1.0310 mL	2.0619 mL	5.1549 mL
	15 mM	0.1375 mL	0.6873 mL	1.3746 mL	3.4366 mL
	20 mM	0.1031 mL	0.5155 mL	1.0310 mL	2.5774 mL
	25 mM	0.0825 mL	0.4124 mL	0.8248 mL	2.0619 mL
	30 mM	0.0687 mL	0.3437 mL	0.6873 mL	1.7183 mL
	40 mM	0.0515 mL	0.2577 mL	0.5155 mL	1.2887 mL
	50 mM	0.0412 mL	0.2062 mL	0.4124 mL	1.0310 mL
	60 mM	0.0344 mL	0.1718 mL	0.3437 mL	0.8591 mL
	80 mM	0.0258 mL	0.1289 mL	0.2577 mL	0.6444 mL
	100 mM	0.0206 mL	0.1031 mL	0.2062 mL	0.5155 mL