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  4. Methylstenbolone

Methylstenbolone is a steroid and an anti-inflammatory agent. Methylstenbolone inhibits nitric oxide production in macrophages and exhibits cytotoxicity against breast cancer cells and normal fibroblasts. Methylstenbolone can be used for the research of inflammation and breast cancer.

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Methylstenbolone

Methylstenbolone Chemische Struktur

CAS. Nr. : 6176-38-1

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Methylstenbolone Related Antibodies

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Beschreibung

Methylstenbolone is a steroid and an anti-inflammatory agent. Methylstenbolone inhibits nitric oxide production in macrophages and exhibits cytotoxicity against breast cancer cells and normal fibroblasts. Methylstenbolone can be used for the research of inflammation and breast cancer[3].

In Vitro

Methylstenbolone (1-25 μg/mL) potently inhibits nitric oxide production in J774.2 mouse macrophage cells with an IC50 of 10.1 μg/mL[3].
Methylstenbolone (6.25-50 µM; 48 h) is cytotoxic to MCF-7 human breast cancer cells (IC50 = 12.26 μg/mL) and toxic to BJ human fibroblast normal cells (IC50 = 8.69 μg/mL), but shows no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methylstenbolone Related Antibodies

Cell Cytotoxicity Assay[3]

Cell Line: MCF-7, NCI-H460, HeLa, BJ human fibroblast normal cells
Concentration: 6.25, 12.5, 25, 50 µM
Incubation Time: 48 h
Result: Exhibited cytotoxicity against MCF-7 breast cancer cells with an IC50 of 12.26 μg/mL.
Showed toxicity toward non-cancerous BJ human fibroblast cells with an IC50 of 8.69 μg/mL.
Showed no cytotoxicity in NCI-H460 human lung cancer cells or HeLa human cervical cancer cells.
In Vivo

Methylstenbolone (1 mg; i.g.; single dose) results in the production and urinary excretion of two dihydroxylated metabolites (U11 and U12) inchimeric and nonchimeric uPA+/+-SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: uPA+/+-SCID chimeric mice transplanted with primary human hepatocytes[1]
Dosage: 1 mg
Administration: i.g.; single dose
Result: Detected no parent methylstenbolone compound and metabolites U1-U10, U13 in chimeric mouse urine.
Detected two dihydroxylated metabolites (U11 and U12) in both chimeric and nonchimeric mouse urine.
Molekulargewicht

316.48

Formel

C21H32O2
CAS. Nr.
SMILES

CC1=C[C@]2([C@H](CC1=O)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(O)C)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
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Methylstenbolone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylstenbolone6176-38-1Drug DerivativeDrug derivativeBJ human fibroblast normal cellsnormal fibroblastsmacrophagesMCF-7 human breast cancer cellsJ774.2 mouse macrophage cellsbreast cancer cellshuman liver microsomeschimeric mouse urineNCI-H460 human lung cancer cellsHeLa human cervical cancer cellsInhibitorinhibitorinhibit

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