2. Apoptosis
  3. Apoptosis
  4. Mimosine

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.

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Mimosine

Mimosine Chemische Struktur

CAS. Nr. : 500-44-7

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Based on 4 publication(s) in Google Scholar

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Mimosine Related Antibodies

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Beschreibung

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

In Vitro

Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2].
Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2].
Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4].
Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4].
Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mimosine Related Antibodies
In Vivo

Mimosine (30, and 60 mg/kg) decreases sperm concentration[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (6-8 weeks)[5]
Dosage: 15, 30, or 60 mg/kg
Administration: Injected (i.p.) for 7 consecutive days
Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
Molekulargewicht

198.18

Formel

C8H10N2O4
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC([C@@H](N)CN1C=CC(C(O)=C1)=O)=O
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 16.67 mg/mL (84.12 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C)

H2O : 5.56 mg/mL (28.06 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0460 mL 25.2298 mL 50.4597 mL
5 mM 1.0092 mL 5.0460 mL 10.0919 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (10.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.97%

SDS (393 KB)

COA (247 KB) HNMR (250 KB) RP-HPLC (255 KB) MS (67 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 5.0460 mL 25.2298 mL 50.4597 mL 126.1492 mL
5 mM 1.0092 mL 5.0460 mL 10.0919 mL 25.2298 mL
10 mM 0.5046 mL 2.5230 mL 5.0460 mL 12.6149 mL
15 mM 0.3364 mL 1.6820 mL 3.3640 mL 8.4099 mL
20 mM 0.2523 mL 1.2615 mL 2.5230 mL 6.3075 mL
25 mM 0.2018 mL 1.0092 mL 2.0184 mL 5.0460 mL
H2O 30 mM 0.1682 mL 0.8410 mL 1.6820 mL 4.2050 mL
40 mM 0.1261 mL 0.6307 mL 1.2615 mL 3.1537 mL
50 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.5230 mL
60 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
80 mM 0.0631 mL 0.3154 mL 0.6307 mL 1.5769 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mimosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mimosine500-44-7Apoptosisantioxidantiron-bindingchelatorFe(III)Anti-cancerantiinflammationanti-fibrosisanti-influenzaanti-virusherbicidainsecticidalInhibitorinhibitorinhibit

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