1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. MK-6884

MK-6884 

Cat. No.: HY-141899
Handling Instructions

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent.

For research use only. We do not sell to patients.

MK-6884 Chemical Structure

MK-6884 Chemical Structure

CAS No. : 2102194-04-5

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Description

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent[1].

IC50 & Target

M4 muscarinic receptor[1]

In Vitro

MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca2+ mobilization assay, with an EC50 of 27 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[11C]MK-6884 (compound 13) shows non-displaceable binding potential (BPND) of 0.83 in rhesus monkeys[1].
[11C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain[1].
[11C]MK-688 can penetrate the blood-brain barrier in monkeys[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.50

Formula

C₂₅H₂₅N₅O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MK-6884
Cat. No.:
HY-141899
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