2. Metabolic Enzyme/Protease
  3. Ferrochelatase
  4. N-Methylprotoporphyrin IX

N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Kiapp value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

N-Methylprotoporphyrin IX

N-Methylprotoporphyrin IX Chemische Struktur

CAS. Nr. : 79236-56-9

Größe Preis Verfügbarkeit Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
5 mg Auf Lager
10 mg   Angebot einholen  
50 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 publication(s) in Google Scholar

N-Methylprotoporphyrin IX Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-Methylprotoporphyrin IX

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Kiapp value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders[1][2].

IC50 & Target

ferrochelatase enzyme[1]
In Vitro

N-Methylprotoporphyrin IX (1 h) exhibits 17.8-fold and 33.3-fold lower binding affinities for the purified ferrochelatase P255R and P255G mutants, respectively, compared with wild-type ferrochelatase (the Kd values of the three are 0.16 ± 0.07 μM, 0.30 ± 0.10 μM, and 9 ± 5 nM, respectively)[1].
N-Methylprotoporphyrin IX inhibits ferrochelatase with an apparent inhibition constant (Kiapp) of 3 nM; in contrast, the P255R and P255G mutants show significantly reduced sensitivity to NMPP, with corresponding Kiapp values of 1 μM and 2.3 μM, respectively[1].
N-methylprotoporphyrin IX dimethyl ester (0.5-20 μM; up to 90 h) potently inhibits the synthesis of phycocyanin and chlorophyll a in C. caldarium cells cultured under light conditions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Methylprotoporphyrin IX Related Antibodies
Molekulargewicht

576.68

Formel

C35H36N4O4
CAS. Nr.
Appearance

Solid

Color

Brown to black

SMILES

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4C)/C(C)=C(C=C)C4=C\C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 15 mg/mL (26.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7341 mL 8.6703 mL 17.3406 mL
5 mM 0.3468 mL 1.7341 mL 3.4681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.0%

SDS (393 KB)

COA (261 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7341 mL 8.6703 mL 17.3406 mL 43.3516 mL
5 mM 0.3468 mL 1.7341 mL 3.4681 mL 8.6703 mL
10 mM 0.1734 mL 0.8670 mL 1.7341 mL 4.3352 mL
15 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8901 mL
20 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1676 mL
25 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7341 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

N-Methylprotoporphyrin IX Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Methylprotoporphyrin IX79236-56-9Ferrochelatasemammalian cellsCyanidium caldarium cellsmouseferrochelatasemitochondrial electron transport complex IVprotoporphyrin IXchlorophyll aphycocyaninEscherichia coli Δvis cellsphycocyanobilinInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
N-Methylprotoporphyrin IX
Art. -Nr.:
HY-129430
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.