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N-Methylpyrrolidone  (Synonyms: NMP; 1-メチル-2-ピロリドン)

製品番号: HY-Y1275 純度: 99.99%
COA 取扱説明書 Technical Support

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.

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N-Methylpyrrolidone

N-Methylpyrrolidone 構造式

CAS 番号 : 872-50-4

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Liquid
50 g $50 在庫あり
100 g $70 在庫あり
500 g $126 在庫あり
1 kg $165 在庫あり

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of N-Methylpyrrolidone:

N-Methylpyrrolidone 関連抗体

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製品説明

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4].

体外実験

N-Methylpyrrolidone (5.0 mM, 11 h) is removed by NJUST38 with the supplementation of nitrate into anoxic system[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Methylpyrrolidone 関連抗体
体内実験

N-Methylpyrrolidone (0-30000 ppm, feed, daily for 28 days) decreases mean body weight gains, shows mild to moderate leukopenia, hypocellular bone marrow, testicular degeneration and atrophy, and thymic atrophy in rats[3][4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[3]
Dosage: 0-30000 ppm
Administration: feed, daily for 28 days
Result: Showed hematological (mild to moderate leukopenia) and histopathological alterations (hypocellular bone marrow, testicular degeneration and atrophy, and thymic atrophy), and cloudy swelling of the epithelia of the distal parts of the renal tubuli in mice.
臨床実験
分子量

99.13

分子式

C5H9NO
CAS 番号
Appearance

Liquid (Density: 1.03 g/mL)

Color

Colorless to light yellow

SMILES

O=C1N(C)CCC1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : Store at room temperature 3 years
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (1008.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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C2

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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% 
+
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%
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.99%

COA (256 KB) HNMR (115 KB) GC (234 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 10.0878 mL 50.4388 mL 100.8776 mL 252.1941 mL
5 mM 2.0176 mL 10.0878 mL 20.1755 mL 50.4388 mL
10 mM 1.0088 mL 5.0439 mL 10.0878 mL 25.2194 mL
15 mM 0.6725 mL 3.3626 mL 6.7252 mL 16.8129 mL
20 mM 0.5044 mL 2.5219 mL 5.0439 mL 12.6097 mL
25 mM 0.4035 mL 2.0176 mL 4.0351 mL 10.0878 mL
30 mM 0.3363 mL 1.6813 mL 3.3626 mL 8.4065 mL
40 mM 0.2522 mL 1.2610 mL 2.5219 mL 6.3049 mL
50 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0439 mL
60 mM 0.1681 mL 0.8406 mL 1.6813 mL 4.2032 mL
80 mM 0.1261 mL 0.6305 mL 1.2610 mL 3.1524 mL
100 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5219 mL
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N-Methylpyrrolidone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Methylpyrrolidone872-50-4NMP 1-Methyl-2-pyrrolidinoneBiochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantscyclic amideorally activeteratogenicity and toxicityadhesivespaintsfuelsand pharmaceuticalsInhibitorinhibitorinhibit

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