N-Methylpyrrolidone-d9
Based on 1 Customer Validation
N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 185964-60-7
- Formula: C5D9NO
- Molecular Weight:108.19
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 185964-60-7
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Unlabeled Cas 872-50-4
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Appearance Liquid (Density: 1.030±0.06 g/cm3)
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Molecular Weight 108.19
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Formula C5D9NO
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Color Colorless to light yellow
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SMILES
O=C1N(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]
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Synonyms
NMP-d9; 1-Methyl-2-pyrrolidinone-d9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 200 mg/mL (1848.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Malek DE, et al. Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP). Drug Chem Toxicol. 1997 Feb-May;20(1-2):63-77. [Content Brief]
[3]. Malley LA, et al. 90-day subchronic toxicity study in rats and mice fed N-methylpyrrolidone (NMP) including neurotoxicity evaluation in rats. Drug Chem Toxicol. 1999 Aug;22(3):455-80. [Content Brief]
[4]. Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185. [Content Brief]
[5]. Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84(1):e02136-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.2430 mL | 46.2150 mL | 92.4300 mL | 231.0750 mL |
| 5 mM | 1.8486 mL | 9.2430 mL | 18.4860 mL | 46.2150 mL | |
| 10 mM | 0.9243 mL | 4.6215 mL | 9.2430 mL | 23.1075 mL | |
| 15 mM | 0.6162 mL | 3.0810 mL | 6.1620 mL | 15.4050 mL | |
| 20 mM | 0.4621 mL | 2.3107 mL | 4.6215 mL | 11.5537 mL | |
| 25 mM | 0.3697 mL | 1.8486 mL | 3.6972 mL | 9.2430 mL | |
| 30 mM | 0.3081 mL | 1.5405 mL | 3.0810 mL | 7.7025 mL | |
| 40 mM | 0.2311 mL | 1.1554 mL | 2.3107 mL | 5.7769 mL | |
| 50 mM | 0.1849 mL | 0.9243 mL | 1.8486 mL | 4.6215 mL | |
| 60 mM | 0.1540 mL | 0.7702 mL | 1.5405 mL | 3.8512 mL | |
| 80 mM | 0.1155 mL | 0.5777 mL | 1.1554 mL | 2.8884 mL | |
| 100 mM | 0.0924 mL | 0.4621 mL | 0.9243 mL | 2.3107 mL |
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