N,S-Bis-Fmoc-Glutathione

Name: N,S-Bis-Fmoc-Glutathione
Brand: MedChemExpress
SKU: HY-P4277
Rating: 4.5 (0 reviews)

Cat. No.: HY-P4277 Pureza: 99.45%: Ficha de datos
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SDS
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N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a K_i value of 0.75 μM and an IC₅₀ of 2.5 μM.

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Síntesis de péptidos personalizados

N,S-Bis-Fmoc-Glutathione Estructura química

No. CAS : 149438-56-2

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of N,S-Bis-Fmoc-Glutathione:

N,S-Bis-Fmoc-Glutathione TFA In-stock

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Actividad biológica
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Revisión del cliente

Descripciòn

N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a K_i value of 0.75 μM and an IC₅₀ of 2.5 μM^[1].

Peso molecular

751.80

Fòrmula

C₄₀H₃₇N₃O₁₀S

No. CAS

149438-56-2

Appearance

Solid

Color

White to off-white

Sequence

{Fmoc}-{γ-Glu(({Cys-Fmoc})-Gly)}

Sequence Shortening

{Fmoc}-{γ-Glu(({Cys-Fmoc})-Gly)}

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (133.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3301 mL	6.6507 mL	13.3014 mL
5 mM	0.2660 mL	1.3301 mL	2.6603 mL
10 mM	0.1330 mL	0.6651 mL	1.3301 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.33 mM); Suspended solution

This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.45%

Select Batch:

Ficha de datos (272 KB) SDS (252 KB)

COA (250 KB) HNMR (394 KB) LCMS (103 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Norton SJ, et al. Inhibitors and inhibition studies of mammalian glyoxalase II activity. Biochem Soc Trans. 1993 May;21(2):545-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3301 mL	6.6507 mL	13.3014 mL	33.2535 mL
	5 mM	0.2660 mL	1.3301 mL	2.6603 mL	6.6507 mL
	10 mM	0.1330 mL	0.6651 mL	1.3301 mL	3.3254 mL
	15 mM	0.0887 mL	0.4434 mL	0.8868 mL	2.2169 mL
	20 mM	0.0665 mL	0.3325 mL	0.6651 mL	1.6627 mL
	25 mM	0.0532 mL	0.2660 mL	0.5321 mL	1.3301 mL
	30 mM	0.0443 mL	0.2217 mL	0.4434 mL	1.1085 mL
	40 mM	0.0333 mL	0.1663 mL	0.3325 mL	0.8313 mL
	50 mM	0.0266 mL	0.1330 mL	0.2660 mL	0.6651 mL
	60 mM	0.0222 mL	0.1108 mL	0.2217 mL	0.5542 mL
	80 mM	0.0166 mL	0.0831 mL	0.1663 mL	0.4157 mL
	100 mM	0.0133 mL	0.0665 mL	0.1330 mL	0.3325 mL