2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Bimatoprost grenod

Bimatoprost grenod  (Synonyms: NCX 470)

Cat. No.: HY-139419 Purity: 98.34%
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Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma.

For research use only. We do not sell to patients.

Bimatoprost grenod Chemical Structure

Bimatoprost grenod Chemical Structure

CAS No. : 1194396-71-8

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 443 In-stock
Solution
10 mM * 1 mL in DMSO USD 443 In-stock
Oil
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

Bimatoprost grenod Related Antibodies

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Description

Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma[1][2].

In Vivo

Bimatoprost grenod shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension[1].
Bimatoprost grenod (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits[2].
Bimatoprost grenod (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection[2]
Dosage: 0.14%
Administration: Instillation; 0.14% 30 μL; once
Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.
Clinical Trial
Molecular Weight

574.71

Formula

C31H46N2O8
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(O[C@@H](CCC1=CC=CC=C1)/C=C/[C@@H]2[C@@H](C/C=C\CCCC(NCC)=O)[C@@H](O)C[C@H]2O)CCCCCO[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7400 mL 8.7000 mL 17.4001 mL
5 mM 0.3480 mL 1.7400 mL 3.4800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7400 mL 8.7000 mL 17.4001 mL 43.5002 mL
5 mM 0.3480 mL 1.7400 mL 3.4800 mL 8.7000 mL
10 mM 0.1740 mL 0.8700 mL 1.7400 mL 4.3500 mL
15 mM 0.1160 mL 0.5800 mL 1.1600 mL 2.9000 mL
20 mM 0.0870 mL 0.4350 mL 0.8700 mL 2.1750 mL
25 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7400 mL
30 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4500 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0875 mL
50 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
60 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7250 mL
80 mM 0.0218 mL 0.1088 mL 0.2175 mL 0.5438 mL
100 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
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Bimatoprost grenod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bimatoprost grenod1194396-71-8NCX 470NCX470NCX-470Prostaglandin Receptorbimatoprostnitric oxidederivativeequimolarcular hypertensionglaucomaInhibitorinhibitorinhibit

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