2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NDT-30805

NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC50 of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity.

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NDT-30805

NDT-30805 構造式

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NDT-30805 関連抗体

Top Publications Citing Use of Products

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NLRP3 NLRP1 NOD1 NOD2

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製品説明

NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC50 of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity[1].

IC50 & Target

NLRP3

 

NLRP3 inflammasome

 

Cellular Effect
Cell Line Type Value Description References
PBMC IC50
>40 μM
Compound: 50;NDT-30805
Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA
Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA
[PMID: 35978696]
PBMC IC50
>40 μM
Compound: 50;NDT-30805
Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA
Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA
[PMID: 35978696]
体外実験

NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NDT-30805 関連抗体

Cell Viability Assay[1]

Cell Line: Human PBMCs
Concentration: 0-2 μM
Incubation Time: 30 min
Result: Inhibited IL-1β release in PBMCs with an IC50 of 0.013 μM.

Cell Viability Assay[1]

Cell Line: THP1-ASC-GFP cells
Concentration: 0-2 μM
Incubation Time: 30 min
Result: Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC50 of 0.034 μM.
分子量

414.53

分子式

C23H22N6S
SMILES

S=C1C=C(CC2=NC=CC=C2)NC3=NC(NC4=C5CCCC5=CC6=C4CCC6)=NN13
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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NDT-30805 Related Classifications

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDT-30805NDT30805NDT 30805NOD-like Receptor (NLR)inflammasomeinterleukin-1inflammationinnate immunityInhibitorinhibitorinhibit

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製品名:
NDT-30805
製品番号:
HY-150965
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