2. Apoptosis
  3. Necroptosis
  4. Necrostatin-1 (inactive control)

Necrostatin-1 (inactive control)  (Synonyms: Nec-1 (inactive control))

製品番号: HY-121954 純度: 99.9%
COA 取扱説明書 Technical Support

Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor.

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Necrostatin-1 (inactive control)

Necrostatin-1 (inactive control) 構造式

CAS 番号 : 64419-92-7

容量 価格（税別） 在庫状況 数量
1 mg $79 在庫あり
5 mg $258 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Necrostatin-1 (inactive control) 関連抗体

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製品説明

Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat EC50
>10 μM
Compound: 48
Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
[PMID: 16153840]
Jurkat EC50
>100 μM
Compound: 5
Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
[PMID: 18408713]
分子量

245.30

分子式

C12H11N3OS
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)C(CC2=CNC3=CC=CC=C32)NC1=S
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMF : 20 mg/mL (81.53 mM; Need ultrasonic and warming)

DMSO : 14 mg/mL (57.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0766 mL 20.3832 mL 40.7664 mL
5 mM 0.8153 mL 4.0766 mL 8.1533 mL
10 mM 0.4077 mL 2.0383 mL 4.0766 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.9%

COA (253 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 4.0766 mL 20.3832 mL 40.7664 mL 101.9160 mL
5 mM 0.8153 mL 4.0766 mL 8.1533 mL 20.3832 mL
10 mM 0.4077 mL 2.0383 mL 4.0766 mL 10.1916 mL
15 mM 0.2718 mL 1.3589 mL 2.7178 mL 6.7944 mL
20 mM 0.2038 mL 1.0192 mL 2.0383 mL 5.0958 mL
25 mM 0.1631 mL 0.8153 mL 1.6307 mL 4.0766 mL
30 mM 0.1359 mL 0.6794 mL 1.3589 mL 3.3972 mL
40 mM 0.1019 mL 0.5096 mL 1.0192 mL 2.5479 mL
50 mM 0.0815 mL 0.4077 mL 0.8153 mL 2.0383 mL
DMF 60 mM 0.0679 mL 0.3397 mL 0.6794 mL 1.6986 mL
80 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2740 mL
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Necrostatin-1 (inactive control) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Necrostatin-1 (inactive control)64419-92-7Nec-1 (inactive control)NecroptosisInhibitorinhibitorinhibit

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製品名:
Necrostatin-1 (inactive control)
製品番号:
HY-121954
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