2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Nolatrexed

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Nolatrexed

Nolatrexed 構造式

CAS 番号 : 147149-76-6

容量 価格（税別） 在庫状況 数量
1 mg $69 お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
5 mg $224 お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
10 mg $402 お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
25 mg $668 お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
50 mg   お問い合わせ  
100 mg   お問い合わせ  
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Based on 2 publication(s) in Google Scholar

Other Forms of Nolatrexed:

Nolatrexed 関連抗体

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製品説明

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.8 μM
Compound: 3
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
[PMID: 9873719]
CCRF-CEM IC50
0.81 μM
Compound: 21
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
GC3/MTK- IC50
1 μM
Compound: 21
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
[PMID: 8459400]
HT-29 IC50
3.7 μM
Compound: 3
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
[PMID: 9873719]
L1210 IC50
1 μM
Compound: 21
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
L1210 IC50
1.1 μM
Compound: 3
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
[PMID: 9873719]
LY3.7.2C TK-/- cell line IC50
1.5 μM
Compound: 3
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
[PMID: 9873719]
分子量

284.34

分子式

C14H12N4OS
CAS 番号
SMILES

O=C1N=C(NC2=CC=C(C)C(SC3=CC=NC=C3)=C12)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Nolatrexed Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nolatrexed147149-76-6AG 337AG337AG-337AntifolateInhibitorinhibitorinhibit

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製品名:
Nolatrexed
製品番号:
HY-13714
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