1. Apoptosis
  2. Thymidylate Synthase
  3. Nolatrexed dihydrochloride

Nolatrexed dihydrochloride (Synonyms: AG 337; Thymitaq)

Cat. No.: HY-108474 Purity: 98.21%
Handling Instructions

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells.

For research use only. We do not sell to patients.

Nolatrexed dihydrochloride Chemical Structure

Nolatrexed dihydrochloride Chemical Structure

CAS No. : 152946-68-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].

IC50 & Target

Ki: 11 nM (Human Thymidylate Synthase)[1]

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (116.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7991 mL 13.9954 mL 27.9908 mL
5 mM 0.5598 mL 2.7991 mL 5.5982 mL
10 mM 0.2799 mL 1.3995 mL 2.7991 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.82 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

357.26

Formula

C₁₄H₁₄Cl₂N₄OS

CAS No.

152946-68-4

SMILES

[H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Nolatrexed dihydrochloride
Cat. No.:
HY-108474
Quantity:

Nolatrexed dihydrochloride

Cat. No.: HY-108474