1. Apoptosis
  2. Thymidylate Synthase
  3. Plevitrexed

Plevitrexed (Synonyms: ZD 9331; BGC9331)

Cat. No.: HY-13728
Handling Instructions

Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical.

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Plevitrexed Chemical Structure

Plevitrexed Chemical Structure

CAS No. : 153537-73-6

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Description

Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical[1][2][3].

In Vitro

ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Ki of∼1 µM[3].

Clinical Trial
Molecular Weight

532.53

Formula

C₂₆H₂₅FN₈O₄

CAS No.

153537-73-6

SMILES

O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[[email protected]](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PlevitrexedZD 9331BGC9331ZD9331ZD-9331BGC 9331BGC-9331Thymidylate Synthaseα-folatereceptorfolatecarriergastriccancerInhibitorinhibitorinhibit

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