(R)-Plevitrexed
(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 153537-74-7
- Formula: C26H25FN8O4
- Molecular Weight:532.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.96 μM
Compound: 36
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Growth inhibition of murine tumor L1210 cell line
Growth inhibition of murine tumor L1210 cell line
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[PMID: 10508430] |
| L1210 | IC50 |
15 nM
Compound: 36
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Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells
Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells
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[PMID: 10508430] |
| L1210 (1565) | IC50 |
23 μM
Compound: 36
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Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines
Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines
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[PMID: 10508430] |
Chemical Information
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CAS No. 153537-74-7
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Molecular Weight 532.53
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Formula C26H25FN8O4
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SMILES
O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2
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Synonyms
(R)-ZD 9331; (R)-BGC9331
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42(19):3809-20. [Content Brief]
[2]. Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56(13):5446-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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