152946-68-4
Chemical Structure
Nolatrexed dihydrochloride
Synonym(s): AG 337
- CAS No.: 152946-68-4
- Formula:C14H14Cl2N4OS
- Molecular Weight:357.26
IUPAC Name: 2-amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(1H)-one dihydrochloride
InChIKey: PJKVJJYMWOCLIJ-UHFFFAOYSA-N
SMILES: [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
Biological Activity: Nolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer.
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Nolatrexed dihydrochloride | 98.47% | Nolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer. | ||||||||||||||||||||
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