2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Nolatrexed

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

For research use only. We do not sell to patients.

Nolatrexed

Nolatrexed Chemical Structure

CAS No. : 147149-76-6

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Based on 2 publication(s) in Google Scholar

Other Forms of Nolatrexed:

Nolatrexed Related Antibodies

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Description

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.8 μM
Compound: 3
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
[PMID: 9873719]
CCRF-CEM IC50
0.81 μM
Compound: 21
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
GC3/MTK- IC50
1 μM
Compound: 21
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
[PMID: 8459400]
HT-29 IC50
3.7 μM
Compound: 3
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
[PMID: 9873719]
L1210 IC50
1 μM
Compound: 21
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
L1210 IC50
1.1 μM
Compound: 3
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
[PMID: 9873719]
LY3.7.2C TK-/- cell line IC50
1.5 μM
Compound: 3
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
[PMID: 9873719]
Molecular Weight

284.34

Formula

C14H12N4OS
CAS No.
SMILES

O=C1N=C(NC2=CC=C(C)C(SC3=CC=NC=C3)=C12)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nolatrexed Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nolatrexed147149-76-6AG 337AG337AG-337AntifolateInhibitorinhibitorinhibit

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HY-13714
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