1. Apoptosis
  2. Thymidylate Synthase
  3. Fosifloxuridine nafalbenamide

Fosifloxuridine nafalbenamide (Synonyms: NUC-3373)

Cat. No.: HY-109115 Purity: 98.18%
Handling Instructions

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy.

For research use only. We do not sell to patients.

Fosifloxuridine nafalbenamide Chemical Structure

Fosifloxuridine nafalbenamide Chemical Structure

CAS No. : 1332837-31-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 675 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 675 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy[1][2].

In Vitro

Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

613.53

Formula

C₂₉H₂₉FN₃O₉P

CAS No.
SMILES

O=P(OC[[email protected]]1O[[email protected]@H](N(C=C(F)C2=O)C(N2)=O)C[[email protected]@H]1O)(N[[email protected]@H](C)C(OCC3=CC=CC=C3)=O)OC4=CC=CC5=C4C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (162.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6299 mL 8.1496 mL 16.2991 mL
5 mM 0.3260 mL 1.6299 mL 3.2598 mL
10 mM 0.1630 mL 0.8150 mL 1.6299 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Fosifloxuridine nafalbenamideNUC-3373NUC3373NUC 3373Thymidylate SynthasefluorodeoxyuridinemonophosphateFdUMP5-fluorouracil5-FU5-fluorodeoxyuridineFUDRanti-cancerInhibitorinhibitorinhibit

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Product Name:
Fosifloxuridine nafalbenamide
Cat. No.:
HY-109115
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