2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Nolatrexed

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Nolatrexed

Nolatrexed Chemische Struktur

CAS. Nr. : 147149-76-6

Größe Preis Verfügbarkeit Menge
1 mg Angebot einholen 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
5 mg Angebot einholen 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
10 mg Angebot einholen 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
25 mg Angebot einholen 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
50 mg   Angebot einholen  
100 mg   Angebot einholen  
Synthetic products have potential research and development risk.

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Other Forms of Nolatrexed:

Nolatrexed Related Antibodies

Top Publications Citing Use of Products

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.8 3
Compound: 3
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
[PMID: 9873719]
CCRF-CEM IC50
0.8 3
Compound: 3
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
Concentration required to inhibit CCRF-CEM (human leukemia) cell lines
[PMID: 9873719]
CCRF-CEM IC50
0.81 3
Compound: 21
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
CCRF-CEM IC50
0.81 3
Compound: 21
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
GC3/MTK- IC50
1 3
Compound: 21
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
[PMID: 8459400]
GC3/MTK- IC50
1 3
Compound: 21
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
[PMID: 8459400]
HT-29 IC50
3.7 3
Compound: 3
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
[PMID: 9873719]
HT-29 IC50
3.7 3
Compound: 3
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
Concentration required to inhibit HT-29 (human colon adenocarcinoma) cell lines
[PMID: 9873719]
L1210 IC50
1 3
Compound: 21
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
L1210 IC50
1.1 3
Compound: 3
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
[PMID: 9873719]
L1210 IC50
1.1 3
Compound: 3
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
Concentration required to inhibit L1210 (mouse lymphocytic leukemia) cell lines
[PMID: 9873719]
L1210 IC50
1 3
Compound: 21
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
Inhibition of mouse L1210 (murine leukemia) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
[PMID: 8459400]
LY3.7.2C TK-/- cell line IC50
1.5 3
Compound: 3
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
[PMID: 9873719]
LY3.7.2C TK-/- cell line IC50
1.5 3
Compound: 3
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
Concentration required to inhibit LY3.7.2C TK-/-(mouse lymphoma, thymidine kinase deficient) cell lines
[PMID: 9873719]
Molekulargewicht

284.34

Formel

C14H12N4OS
CAS. Nr.
SMILES

O=C1N=C(NC2=CC=C(C)C(SC3=CC=NC=C3)=C12)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Nolatrexed Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nolatrexed147149-76-6AG 337AG337AG-337AntifolateInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
Nolatrexed
Art. -Nr.:
HY-13714
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.