Ostarine (Synonyms: MK-2866; GTX-024; Enobosarm)

Name: Ostarine
Brand: MedChemExpress
SKU: HY-13273
Rating: 5.0 (3 reviews)

製品番号: HY-13273 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Ostarine 構造式

CAS 番号 : 841205-47-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 71	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 71	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$65	在庫あり	Estimated Time of Arrival: December 31
10 mg	$95	在庫あり	Estimated Time of Arrival: December 31
25 mg	$145	在庫あり	Estimated Time of Arrival: December 31
50 mg	$190	在庫あり	Estimated Time of Arrival: December 31
100 mg	$250	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Other Forms of Ostarine:

Ostarine-d₄ お問い合わせ

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	24.77 μM Compound: 44e; S-Enobosarm	Antiproliferative activity against human 22Rv1 cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay Antiproliferative activity against human 22Rv1 cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay	[PMID: 27131065]
DU-145	IC₅₀	44.55 μM Compound: 44e; S-Enobosarm	Antiproliferative activity against human DU145 cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay Antiproliferative activity against human DU145 cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay	[PMID: 27131065]
HEK293	IC₅₀	0.0038 μM Compound: 2	Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hrs by luciferase reporter gene assay Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hrs by luciferase reporter gene assay	[PMID: 30525603]
LNCaP	IC₅₀	20.9 μM Compound: 44e; S-Enobosarm	Antiproliferative activity against human LNCAP cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay Antiproliferative activity against human LNCAP cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay	[PMID: 27131065]
VCaP	IC₅₀	24.47 μM Compound: 44e; S-Enobosarm	Antiproliferative activity against human VCaP cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay Antiproliferative activity against human VCaP cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay	[PMID: 27131065]

体外実験

Ostarine (1000, 10000 nM) modulates the differentiation of H9C2 cardiomyocytes^[1].
Ostarine (1, 10, 100, 1000, 10000 nM) stimulates proliferation, cell viability, and differentiation of C2C12 and L6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1].

Cell Line:	H9C2 cell
Concentration:	1000, 10000 nM
Incubation Time:	48 h
Result:	Increased production of myosin protein

Cell Proliferation Assay^[2].

Cell Line:	C2C12 and L6 cells
Concentration:	1, 10, 100, 1000, 10000 nM
Incubation Time:	48 h
Result:	Increased proliferation of C2C12 and L6 cells

Cell Viability Assay^[2].

Cell Line:	C2C12 and L6 cells
Concentration:	1, 10, 100, 1000, 10000 nM
Incubation Time:	48 h
Result:	Increased cell viability of C2C12 and L6 cells

体内実験

Ostarine (0.4 mg/kg, 30 days, s.c.) stimulates profibrotic changes in male rat heart^[1].
Ostarine (0.4 mg/kg, 30 days, s.c.) stimulates muscle tissue proliferation and differentiation via the androgen receptor in rats sup>[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats^[1].
Dosage:	0.4 mg/kg, 30 days
Administration:	Subcutaneous injection (s.c.)
Result:	Increased the production of βMhc protein and the expression of βMhc, Tgfβ, Αsma, fibronectin, and BNP mRNA

Animal Model:	Male Wistar rats^[2].
Dosage:	0.4 mg/kg, 30 days
Administration:	Subcutaneous injection (s.c.)
Result:	Increased the expression of myogenin mRNA, myh mRNA and MyH protein content

臨床実験

分子量

389.33

分子式

C₁₉H₁₄F₃N₃O₃

CAS 番号

841205-47-8

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=C(C=CC(NC([C@@](C)(O)COC2=CC=C(C=C2)C#N)=O)=C1)C#N)F

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (256.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5685 mL	12.8426 mL	25.6852 mL
5 mM	0.5137 mL	2.5685 mL	5.1370 mL
10 mM	0.2569 mL	1.2843 mL	2.5685 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.42 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.90%

Select Batch:

データシート (276 KB) SDS (393 KB)

COA (246 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Leciejewska N, et al. Sex-specific cytotoxicity of ostarine in cardiomyocytes. Mol Cell Endocrinol. 2023 Nov 1;577:112037. [Content Brief]

[2]. Leciejewska N, et al. Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles. Int J Mol Sci. 2022 Apr 15;23(8):4404. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5685 mL	12.8426 mL	25.6852 mL	64.2129 mL
	5 mM	0.5137 mL	2.5685 mL	5.1370 mL	12.8426 mL
	10 mM	0.2569 mL	1.2843 mL	2.5685 mL	6.4213 mL
	15 mM	0.1712 mL	0.8562 mL	1.7123 mL	4.2809 mL
	20 mM	0.1284 mL	0.6421 mL	1.2843 mL	3.2106 mL
	25 mM	0.1027 mL	0.5137 mL	1.0274 mL	2.5685 mL
	30 mM	0.0856 mL	0.4281 mL	0.8562 mL	2.1404 mL
	40 mM	0.0642 mL	0.3211 mL	0.6421 mL	1.6053 mL
	50 mM	0.0514 mL	0.2569 mL	0.5137 mL	1.2843 mL
	60 mM	0.0428 mL	0.2140 mL	0.4281 mL	1.0702 mL
	80 mM	0.0321 mL	0.1605 mL	0.3211 mL	0.8027 mL
	100 mM	0.0257 mL	0.1284 mL	0.2569 mL	0.6421 mL

Ostarine Related Classifications

Cancer Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ostarine841205-47-8MK-2866 GTX-024 EnobosarmMK2866MK 2866GTX024GTX 024GTX-024Androgen ReceptorH9C2 cellC2C12 cellL6 cellInhibitorinhibitorinhibit

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Ostarine (Synonyms: MK-2866; GTX-024; Enobosarm)

カスタマーレビュー

Other Forms of Ostarine:

Ostarine 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Ostarine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ostarine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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