p-Toluenesulfonic acid monohydrate (Synonyms: PTSA monohydrate)

Name: p-Toluenesulfonic acid monohydrate
Brand: MedChemExpress
SKU: HY-W015175
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Cat. No.: HY-W015175 Pureza: 99.75%: Ficha de datos
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p-Toluenesulfonic acid (PTSA) monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis .

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p-Toluenesulfonic acid monohydrate Estructura química

No. CAS : 6192-52-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 g	En stock	Estimated Time of Arrival: December 31
500 g	En stock	Estimated Time of Arrival: December 31
1 kg	En stock	Estimated Time of Arrival: December 31

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Other Forms of p-Toluenesulfonic acid monohydrate:

p-Toluenesulfonic acid-d₇ monohydrate In-stock
p-Toluenesulfonic acid monohydrate (Standard) In-stock

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Descripciòn

p-Toluenesulfonic acid (PTSA) monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis ^[1]^[2]^[3]^[4].

In Vitro

p-Toluenesulfonic acid monohydrate exhibits remarkable reactivity as a homogenous organocatalyst^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

190.22

Fòrmula

C₇H₁₀O₄S

No. CAS

6192-52-5

Appearance

Solid

Color

White to pink

SMILES

CC1=CC=C(S(O)(=O)=O)C=C1.O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (525.71 mM; Need ultrasonic)

DMSO : 50 mg/mL (262.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2571 mL	26.2854 mL	52.5707 mL
5 mM	1.0514 mL	5.2571 mL	10.5141 mL
10 mM	0.5257 mL	2.6285 mL	5.2571 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.95%

Select Batch:

Ficha de datos (276 KB) SDS (617 KB)

COA (253 KB) HNMR (115 KB) RP-HPLC (345 KB) MS (153 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Tashiro S, et al. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions. Chem Commun (Camb). 2016 Jun 8;52(49):7657-60. [Content Brief]

[2]. Quan XJ, et al. p-Toluenesulfonic acid mediated 1,3-dipolar cycloaddition of nitroolefins with NaN3 for synthesis of 4-aryl-NH-1,2,3-triazoles. Org Lett. 2014 Nov 7;16(21):5728-31. [Content Brief]

[3]. Pejov L, et al. Quantum chemical study of p-toluenesulfonic acid, p-toluenesulfonate anion and the water-p-toluenesulfonic acid complex. Comparison with experimental spectroscopic data. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):27-34. [Content Brief]

[4]. Mousavi M R, et al. Catalytic systems containing p-toluenesulfonic acid monohydrate catalyzed the synthesis of triazoloquinazolinone and benzimidazoquinazolinone derivatives[J]. Monatshefte für Chemie-Chemical Monthly, 2014, 145: 1967-1973.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.2571 mL	26.2854 mL	52.5707 mL	131.4268 mL
	5 mM	1.0514 mL	5.2571 mL	10.5141 mL	26.2854 mL
	10 mM	0.5257 mL	2.6285 mL	5.2571 mL	13.1427 mL
	15 mM	0.3505 mL	1.7524 mL	3.5047 mL	8.7618 mL
	20 mM	0.2629 mL	1.3143 mL	2.6285 mL	6.5713 mL
	25 mM	0.2103 mL	1.0514 mL	2.1028 mL	5.2571 mL
	30 mM	0.1752 mL	0.8762 mL	1.7524 mL	4.3809 mL
	40 mM	0.1314 mL	0.6571 mL	1.3143 mL	3.2857 mL
	50 mM	0.1051 mL	0.5257 mL	1.0514 mL	2.6285 mL
	60 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1904 mL
	80 mM	0.0657 mL	0.3286 mL	0.6571 mL	1.6428 mL
	100 mM	0.0526 mL	0.2629 mL	0.5257 mL	1.3143 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

p-Toluenesulfonic acid monohydrate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Toluenesulfonic acid6192-52-5PTSABiochemical Assay ReagentsEnvironmental PollutantsEnvironmental ContaminantsOrganiccatalystsynthesisInhibitorinhibitorinhibit

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p-Toluenesulfonic acid monohydrate (Synonyms: PTSA monohydrate)

Revisión del cliente

Other Forms of p-Toluenesulfonic acid monohydrate:

p-Toluenesulfonic acid monohydrate Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

p-Toluenesulfonic acid monohydrate Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

p-Toluenesulfonic acid monohydrate Related Classifications

Keywords:

Productos vistos recientemente:

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