p-Toluenesulfonic acid-d7 monohydrate
Based on 1 Customer Validation
p-Toluenesulfonic acid-d7 (monohydrate) is the deuterium labeled p-Toluenesulfonic acid monohydrate. p-Toluenesulfonic acid monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 1219795-22-8
- Formula: C7H3D7O4S
- Molecular Weight:197.26
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219795-22-8
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Unlabeled Cas 104-15-4
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Appearance Solid
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Molecular Weight 197.26
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Formula C7H3D7O4S
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Color White to off-white
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SMILES
O=S(O)(C1=C([2H])C([2H])=C(C([2H])=C1[2H])C([2H])([2H])[2H])=O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 100 mg/mL (506.95 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Tashiro S, et al. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions. Chem Commun (Camb). 2016 Jun 8;52(49):7657-60. [Content Brief]
[3]. Quan XJ, et al. p-Toluenesulfonic acid mediated 1,3-dipolar cycloaddition of nitroolefins with NaN3 for synthesis of 4-aryl-NH-1,2,3-triazoles. Org Lett. 2014 Nov 716(21):5728-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0695 mL | 25.3473 mL | 50.6945 mL | 126.7363 mL |
| 5 mM | 1.0139 mL | 5.0695 mL | 10.1389 mL | 25.3473 mL | |
| 10 mM | 0.5069 mL | 2.5347 mL | 5.0695 mL | 12.6736 mL | |
| 15 mM | 0.3380 mL | 1.6898 mL | 3.3796 mL | 8.4491 mL | |
| 20 mM | 0.2535 mL | 1.2674 mL | 2.5347 mL | 6.3368 mL | |
| 25 mM | 0.2028 mL | 1.0139 mL | 2.0278 mL | 5.0695 mL | |
| 30 mM | 0.1690 mL | 0.8449 mL | 1.6898 mL | 4.2245 mL | |
| 40 mM | 0.1267 mL | 0.6337 mL | 1.2674 mL | 3.1684 mL | |
| 50 mM | 0.1014 mL | 0.5069 mL | 1.0139 mL | 2.5347 mL | |
| 60 mM | 0.0845 mL | 0.4225 mL | 0.8449 mL | 2.1123 mL | |
| 80 mM | 0.0634 mL | 0.3168 mL | 0.6337 mL | 1.5842 mL | |
| 100 mM | 0.0507 mL | 0.2535 mL | 0.5069 mL | 1.2674 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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