p-Toluenesulfonic acid monohydrate
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p-Toluenesulfonic acid (PTSA) monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis .
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- Pureza: 99.95%
- No. CAS: 6192-52-5
- Fòrmula: C7H10O4S
- Peso molecular:190.22
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Almacenamiento:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
p-Toluenesulfonic acid monohydrate exhibits remarkable reactivity as a homogenous organocatalyst[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 6192-52-5
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Appearance Solid
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Peso molecular 190.22
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Fòrmula C7H10O4S
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Color White to pink
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SMILES
CC1=CC=C(S(O)(=O)=O)C=C1.O
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Synonyms
PTSA monohydrate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvente y solubilidad
H2O : 100 mg/mL (525.71 mM; Need ultrasonic)
DMSO : 50 mg/mL (262.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.14 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (617 KB)
- English - EN (617 KB)
- Français - FR (617 KB)
- Deutsch - DE (617 KB)
- Norwegian - NO (617 KB)
- Español - ES (617 KB)
- Swedish - SV (617 KB)
- Italian - IT (617 KB)
- Korean - KR (617 KB)
- Portuguese - PT (617 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tashiro S, et al. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions. Chem Commun (Camb). 2016 Jun 8;52(49):7657-60. [Content Brief]
[2]. Quan XJ, et al. p-Toluenesulfonic acid mediated 1,3-dipolar cycloaddition of nitroolefins with NaN3 for synthesis of 4-aryl-NH-1,2,3-triazoles. Org Lett. 2014 Nov 7;16(21):5728-31. [Content Brief]
[3]. Pejov L, et al. Quantum chemical study of p-toluenesulfonic acid, p-toluenesulfonate anion and the water-p-toluenesulfonic acid complex. Comparison with experimental spectroscopic data. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):27-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.2571 mL | 26.2854 mL | 52.5707 mL | 131.4268 mL |
| 5 mM | 1.0514 mL | 5.2571 mL | 10.5141 mL | 26.2854 mL | |
| 10 mM | 0.5257 mL | 2.6285 mL | 5.2571 mL | 13.1427 mL | |
| 15 mM | 0.3505 mL | 1.7524 mL | 3.5047 mL | 8.7618 mL | |
| 20 mM | 0.2629 mL | 1.3143 mL | 2.6285 mL | 6.5713 mL | |
| 25 mM | 0.2103 mL | 1.0514 mL | 2.1028 mL | 5.2571 mL | |
| 30 mM | 0.1752 mL | 0.8762 mL | 1.7524 mL | 4.3809 mL | |
| 40 mM | 0.1314 mL | 0.6571 mL | 1.3143 mL | 3.2857 mL | |
| 50 mM | 0.1051 mL | 0.5257 mL | 1.0514 mL | 2.6285 mL | |
| 60 mM | 0.0876 mL | 0.4381 mL | 0.8762 mL | 2.1904 mL | |
| 80 mM | 0.0657 mL | 0.3286 mL | 0.6571 mL | 1.6428 mL | |
| 100 mM | 0.0526 mL | 0.2629 mL | 0.5257 mL | 1.3143 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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