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PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model.

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PAA4

PAA4 Estructura química

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PAA4 Related Antibodies

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Descripciòn

PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model[1].

In Vitro

PAA4 (0-4 µM; 24 h) shows no significant cytotoxicity in EJ, HUVEC, SV-HUC-1 cell lines with IC50 values of 2.1, 0.80, 2.3 µM, respectively[1].
PAA4 (4 µM; 1, 3, 6 h) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAA4 Related Antibodies

Cell Viability Assay[1]

Cell Line: HUVEC, EJ, SV-HUC-1 cells
Concentration: 0, 0.5, 1, 1.5, 2, 4 µM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity in EJ, HUVEC, SV-HUC-1 cell lines with IC50 values of 2.1, 0.80, 2.3 µM, respectively.

Western Blot Analysis[1]

Cell Line: EJ cells
Concentration: 4 µM
Incubation Time: 1, 3, 6 h
Result: Increased the expression of pH2AX in a time dependent manner.
In Vivo

PAA4 (1.5 µM, 100 µL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, 18 g, female BALB/c nude mice[1]
Dosage: 1.5 µM, 100 µL
Administration: Intravesical delivered into the bladder; 5 times every other day for 8 days
Result: Exhibited a good anti-tumor effect with the small average tumor volume of 564 ± 180 mm3 after 22 days and no significant body weight loss.
Peso molecular

1064.89

Fòrmula

C14H8Au4BF4N
SMILES

[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au]5[Au]2[Au]3[Au]45)=NC6=C7C=CC=C6)=C7C=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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PAA4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAA4PAA 4PAA-4OthersantiproliferativeEJ cellspH2AXanti-tumororthotopic bladder cancerInhibitorinhibitorinhibit

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Nombre del producto:
PAA4
Cat. No.:
HY-149035
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