PF-00277343 

PF-00277343 is a selective and skin-penetrable THR-β (K_i: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models^[1].

PF-00277343 is rapidly metabolized in rat liver microsomes (HLM t_1/2 = 40 min), in rat hepatocytes, its half-life is 45 min, clearance CL_blood is 51 mL/min/kg and CL_int is 149 mL/min/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-00277343 (1 mg/mL and 0.1 mg/mL, single topical application) is effective in inducing hair growth in C3H female mice^[1].
PF-00277343 (i.v., 0.5 mg/kg) shows thhe mean systemic plasma clearance of 40 mL/min/kg, the mean apparent volume of distribution at steady state of 4.88 mL/min/kg, and the mean terminal phase half-life of 2.73 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

433.43

C₂₄H₂₀FN₃O₄

332926-04-2

O=C(N(N=C1)C2=CC(C)=C(C(C)=C2)OC3=CC=C(C(CC4=CC=C(C=C4)F)=C3)O)NC1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li JJ, et al. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010 Jan 1;20(1):306-8.  [Content Brief]