1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [(pF)Phe4]Nociceptin(1-13)NH2 TFA

[(pF)Phe4]Nociceptin(1-13)NH2 TFA 

Cat. No.: HY-P1300A
Handling Instructions

[(pF)Phe4]Nociceptin(1-13)NH2 TFA is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 TFA displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).

For research use only. We do not sell to patients.

[(pF)Phe4]Nociceptin(1-13)NH2 TFA Chemical Structure

[(pF)Phe4]Nociceptin(1-13)NH2 TFA Chemical Structure

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Other Forms of [(pF)Phe4]Nociceptin(1-13)NH2 TFA:

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Description

[(pF)Phe4]Nociceptin(1-13)NH2 TFA is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 TFA displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].

In Vivo

In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 TFA decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].

Molecular Weight

1513.60

Formula

C₆₃H₁₀₀F₄N₂₂O₁₇

Sequence Shortening

FGG{Phe(4-F)}TGARKSARK-NH2

SMILES

[FGG{Phe(4-F)}TGARKSARK-NH2 (TFA salt)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

[(pF)Phe4]Nociceptin(1-13)NH2Opioid ReceptorselectivityhypotensivefeedingnociceptionInhibitorinhibitorinhibit

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Product Name:
[(pF)Phe4]Nociceptin(1-13)NH2 TFA
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HY-P1300A
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