[(pF)Phe4]Nociceptin(1-13)NH2
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).
For research use only. We do not sell to patients.
- CAS No.: 380620-88-2
- Formula: C61H99FN22O15
- Molecular Weight:1399.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[(pF)Phe4]Nociceptin(1-13)NH2 Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p1300.gif "Click to View [(pF)Phe4]Nociceptin(1-13)NH2 Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
![[Nphe1]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p1320.gif)
![[Arg14,Lys15]Nociceptin](https://file.medchemexpress.com/product_pic/hy-p1301.gif)
All Opioid Receptor Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 380620-88-2
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Molecular Weight 1399.58
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Formula C61H99FN22O15
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Sequence Shortening
FGG{Phe(4-F)}TGARKSARK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456. [Content Brief]
[2]. Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449. [Content Brief]
[3]. Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[(pF)Phe4]Nociceptin(1-13)NH2 Related Classifications
HY-P1300 Related Classifications
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