1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [Arg14,Lys15]Nociceptin

[Arg14,Lys15]Nociceptin 

Cat. No.: HY-P1301
Handling Instructions

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively.

For research use only. We do not sell to patients.

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[Arg14,Lys15]Nociceptin Chemical Structure

[Arg14,Lys15]Nociceptin Chemical Structure

CAS No. : 236098-40-1

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Description

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

In Vitro

[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

In Vivo

In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

Molecular Weight

1909.16

Formula

C₈₂H₁₃₇N₃₁O₂₂

CAS No.

236098-40-1

Sequence Shortening

FGGFTGARKSARKRKNQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

[Arg14,Lys15]NociceptinOpioid ReceptorselectivitylocomotornociceptionanalogorphaninInhibitorinhibitorinhibit

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[Arg14,Lys15]Nociceptin
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