[Arg14,Lys15]Nociceptin
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively.
For research use only. We do not sell to patients.
- CAS No.: 236098-40-1
- Formula: C82H137N31O22
- Molecular Weight:1909.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Arg14,Lys15]Nociceptin Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p1301.gif "Click to View [Arg14,Lys15]Nociceptin Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | EC50 |
1.1 nM
Compound: 1, [RK14-15]Noc
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Agonist activity at rat ORL1 receptor expressed in african green monkey COS7 cells assessed as stimulation of [35S]GTPgammaS binding by radioligand receptor-binding assay
Agonist activity at rat ORL1 receptor expressed in african green monkey COS7 cells assessed as stimulation of [35S]GTPgammaS binding by radioligand receptor-binding assay
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[PMID: 19577933] |
| COS-7 | EC50 |
1.1 nM
Compound: 3, [RK14-15]Noc
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Activation of rat ORL1 receptor expressed in african green monkey COS7 cells by [35S]GTPgammaS binding assay
Activation of rat ORL1 receptor expressed in african green monkey COS7 cells by [35S]GTPgammaS binding assay
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[PMID: 18818087] |
| COS-7 | IC50 |
0.21 nM
Compound: 1, [RK14-15]Noc
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Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells by competitive binding assay
Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells by competitive binding assay
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[PMID: 19577933] |
[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 236098-40-1
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Molecular Weight 1909.16
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Formula C82H137N31O22
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Sequence Shortening
FGGFTGARKSARKRKNQ
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498. [Content Brief]
[2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[Arg14,Lys15]Nociceptin Related Classifications
HY-P1301 Related Classifications
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