[Nphe1]Nociceptin(1-13)NH2
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent.
For research use only. We do not sell to patients.
- CAS No.: 267234-08-2
- Formula: C61H100N22O15
- Molecular Weight:1381.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Nphe1]Nociceptin(1-13)NH2 Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p1320.gif "Click to View [Nphe1]Nociceptin(1-13)NH2 Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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All Opioid Receptor Isoforms
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Biological Activity
[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 267234-08-2
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Molecular Weight 1381.59
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Formula C61H100N22O15
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Sequence Shortening
Bn-GGGFTGARKSARK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor [Content Brief]
[2]. G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1183-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[Nphe1]Nociceptin(1-13)NH2 Related Classifications
HY-P1320 Related Classifications
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