1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [Nphe1]Nociceptin(1-13)NH2

[Nphe1]Nociceptin(1-13)NH2 

Cat. No.: HY-P1320
Handling Instructions

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Nphe1]Nociceptin(1-13)NH2 Chemical Structure

[Nphe1]Nociceptin(1-13)NH2 Chemical Structure

CAS No. : 267234-08-2

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Description

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].

In Vitro

[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).

Molecular Weight

1381.59

Formula

C₆₁H₁₀₀N₂₂O₁₅

CAS No.

267234-08-2

Sequence Shortening

Bn-GGGFTGARKSARK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

[Nphe1]Nociceptin(1-13)NH2Opioid Receptoranalgesic agentInhibitorinhibitorinhibit

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[Nphe1]Nociceptin(1-13)NH2
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