Phycocyanobilin

Name: Phycocyanobilin
Brand: MedChemExpress
SKU: HY-130750
Rating: 4.5 (0 reviews)

製品番号: HY-130750 純度: 98.90%: Data Sheet SDS COA 取扱説明書
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Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Phycocyanobilin 構造式

CAS 番号 : 20298-86-6

容量	価格（税別）	在庫状況	数量
1 mg	$475	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1190	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1900	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease^[1]^[2]^[3].

体外実験

Phycocyanobilin (100 μM; 0-250 min) inhibits the peroxidation of methyl linoleate and produces a prolonged induction period^[1].
Phycocyanobilin (1 mM; 0-300 min) suppresses the oxidation of the liposomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) shows antioxidant effects in type 2 diabetes mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes^[3]
Dosage:	15 mg/kg
Administration:	In diet for 2 weeks
Result:	Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF_2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.

分子量

586.68

分子式

C₃₃H₃₈N₄O₆

CAS 番号

20298-86-6

Appearance

Solid

Color

Blue to dark blue

SMILES

O=C(NC/1=C\C2=C(C)C(CCC(O)=O)=C(/C=C3C(CCC(O)=O)=C(C(/C=C(C(C)=C4CC)\NC4=O)=N/3)C)N2)[C@H](C)C1=C\C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Spirulina platensis

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 10 mg/mL (17.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7045 mL	8.5225 mL	17.0451 mL
5 mM	0.3409 mL	1.7045 mL	3.4090 mL
10 mM	0.1705 mL	0.8523 mL	1.7045 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.90%

Select Batch:

データシート (278 KB) SDS (393 KB)

COA (258 KB) HNMR (508 KB) RP-HPLC (270 KB) LCMS (104 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hirata T, et al. Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. Journal of Applied Phycology, 2000, 12: 435-439.

[2]. Matamoros BP, et al. Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer's disease. J Biosci. 2021;46:42. [Content Brief]

[3]. Zheng J, et al. Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R110-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7045 mL	8.5225 mL	17.0451 mL	42.6127 mL
	5 mM	0.3409 mL	1.7045 mL	3.4090 mL	8.5225 mL
	10 mM	0.1705 mL	0.8523 mL	1.7045 mL	4.2613 mL
	15 mM	0.1136 mL	0.5682 mL	1.1363 mL	2.8408 mL