Plasma kallikrein-IN-4

Art. -Nr.: HY-153115 Reinheit: 98.61%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC₅₀ of 0.016 μM against human plasma kallikrein.

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Plasma kallikrein-IN-4 Chemische Struktur

CAS. Nr. : 1357954-34-7

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Kallikrein Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC₅₀ of 0.016 μM against human plasma kallikrein^[1].

IC₅₀ & Target

IC50: 0.016 μM (human plasma kallikrein)^[1]

Molekulargewicht

401.46

Formel

C₂₂H₂₃N₇O

CAS. Nr.

1357954-34-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC2=CC3=C(N=C(C)C=C3)C=C2)N=N1)NCC4=C(C)C=C(N)N=C4C

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (249.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4909 mL	12.4545 mL	24.9091 mL
5 mM	0.4982 mL	2.4909 mL	4.9818 mL
10 mM	0.2491 mL	1.2455 mL	2.4909 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.61%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (247 KB) HNMR (138 KB) RP-HPLC (169 KB) LCMS (356 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Trixi Brandl, et al. N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein. Patent WO2012017020A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4909 mL	12.4545 mL	24.9091 mL	62.2727 mL
	5 mM	0.4982 mL	2.4909 mL	4.9818 mL	12.4545 mL
	10 mM	0.2491 mL	1.2455 mL	2.4909 mL	6.2273 mL
	15 mM	0.1661 mL	0.8303 mL	1.6606 mL	4.1515 mL
	20 mM	0.1245 mL	0.6227 mL	1.2455 mL	3.1136 mL
	25 mM	0.0996 mL	0.4982 mL	0.9964 mL	2.4909 mL
	30 mM	0.0830 mL	0.4152 mL	0.8303 mL	2.0758 mL
	40 mM	0.0623 mL	0.3114 mL	0.6227 mL	1.5568 mL
	50 mM	0.0498 mL	0.2491 mL	0.4982 mL	1.2455 mL
	60 mM	0.0415 mL	0.2076 mL	0.4152 mL	1.0379 mL
	80 mM	0.0311 mL	0.1557 mL	0.3114 mL	0.7784 mL
	100 mM	0.0249 mL	0.1245 mL	0.2491 mL	0.6227 mL