PLGA (50:50) (Synonyms: poly(lactic-co-glycolic acid) (50:50))

Name: PLGA (50:50)
Brand: MedChemExpress
SKU: HY-B2247
Rating: 5.0 (29 reviews)

Cat. No.: HY-B2247 Assay: 99.41%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 34346-01-5

Tamaño	Stock	Cantidad
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
2 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
10 g	Obtener un presupuesto
50 g	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 29 publication(s) in Google Scholar

Other Forms of PLGA (50:50):

PLGA (75:25) In-stock

29 Publications Citing Use of MCE PLGA (50:50)

Bio/Physico-chemical Assay

: PLGA (50:50) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 21:e2412799. [Abstract]; Hydrodynamic sizes of PLGA (10 mg/mL; 4 h) cores, MΦ NPs, OLA@MΦ NPs, and OLA@MΦ NPs-2 (OLA@MΦ NPs isolated from cp-OLA@MΦ NPs) were measured (n = 3).

: PLGA (50:50) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 21:e2412799. [Abstract]; PLGA (10 mg/mL; 4 h). TEM images of PLGA cores and OLA@MΦ NPs-2 were obtained.

: PLGA (50:50) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 21:e2412799. [Abstract]; PLGA (10 mg/mL; 4 h). Western blot analysis of IL-1R, IL-6R, TNFR, and TLR4 in PLGA cores, MΦ NPs, OLA@MΦ NPs, and OLA@MΦ NPs-2.

: PLGA (50:50) purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Sep;129:110371. [Abstract]; Immunofluorescence staining displays weaker Bcl-2 fluorescence intensity in lung cancer cells incubated with RBCm-Obatoclax Mesylate (OM)/PLGA, accompanied with stronger expression of pro-apoptotic signal Bax in comparison to the Con group.

: PLGA (50:50) purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Sep;129:110371. [Abstract]; Bcl-2 and Bcl-xl protein expression levels are restrained in A549 and H1975 cells treated with RBCm-OM/PLGA; however, Bax, cleaved Caspase-3, Caspase-9 and PARP are up-regulated following RBCm-OM/PLGA incubation. Also, free Obatoclax Mesylate (OM) does not influence the expression change of all these proteins.

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

In Vitro

PLGA (50:50) can be used to prepare nanoparticles with different surface properties for biological experiments^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

10000-20000

Fòrmula

(C₃H₆O₃)n.(C₂H₄O₃)n

No. CAS

34346-01-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(C)OC(CO[H])=O.[x].[y]

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.41%

Select Batch:

Ficha de datos (269 KB) SDS (252 KB)

COA (243 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Makadia HK, et al. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers (Basel). 2011 Sep 1;3(3):1377-1397. [Content Brief]

[2]. Chung TW, Tsai YL, Hsieh JH, Tsai WJ. Different ratios of lactide and glycolide in PLGA affect the surface property and protein delivery characteristics of the PLGA microspheres with hydrophobic additives. J Microencapsul. 2006;23(1):15-27. [Content Brief]

[3]. Mura S, et al. Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells. Int J Nanomedicine. 2011;6:2591-605. [Content Brief]

PLGA (50:50) Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLGA (50:50)34346-01-5poly(lactic-co-glycolic acid) (50:50)Biochemical Assay ReagentsInhibitorinhibitorinhibit

Productos vistos recientemente:

Nombre del producto

Requested Quantity *

Nombre del solicitante *

Saludo

Direcciòn del E-mail *

Número de teléfono *

Department

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

Observaciones

Nombre del producto

Lot #

Nombre del solicitante *

Direcciòn del E-mail *

Número de teléfono

Department *

Nombre de la Organizaciòn *

Country or Region *

Observaciones

Name
E-mail *

	Sorry, but the email address you supplied was invalid.

PLGA (50:50) (Synonyms: poly(lactic-co-glycolic acid) (50:50))

Revisión del cliente

Other Forms of PLGA (50:50):

PLGA (50:50) Related Antibodies

29 Publications Citing Use of MCE PLGA (50:50)

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

PLGA (50:50) Related Antibodies

Calculadora de molaridad

Calculadora de dilución

PLGA (50:50) Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report