Poloxamer 124 (L44)  (Synonyms: PEG-PPG-PEG, 2200 (Average))

Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD₅₀ of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].

Poloxamer 124 (L44) (Pluronic L-81) (0.17 mg/mL, 3 mL/h; intragastrically, for 1 h) significantly reduces the transport of triglycerides and cholesterol and the export of phospholipids in the lymphatic system of rats, without affecting the digestive and absorptive functions of rats (the recovery rates of lipids and cholesterol in the intestinal lumen of rats do not change significantly). This indicates that Poloxamer 124 (L44) interferes with the assembly of lipoproteins and/or the excretion of lipoproteins from mucosal cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2200 (Average)

9003-11-6

Solid-Liquid Mixture

Colorless to off-white

[Poloxamer 124 (L44)]

Room temperature in continental US; may vary elsewhere.

• [1]. Singh-Joy SD, et al., Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics. Int J Toxicol. 2008;27 Suppl 2:93-128.  [Content Brief]

  [2]. Li Y, et al., Ultra-high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry method for quantifying polymer poloxamer 124 and its application to pharmacokinetic study. J Sep Sci. 2021 Oct;44(20):3822-3829.  [Content Brief]

  [3]. Tso P, et al. Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat. Am J Physiol. 1980 Nov;239(5):G348-53.  [Content Brief]