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Poloxamer 188  (Synonyms: PEG-PPG-PEG, 8800 (Average Mn))

製品番号: HY-D1005A
COA 取扱説明書 Technical Support

Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery.

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Poloxamer 188

Poloxamer 188 構造式

CAS 番号 : 9003-11-6

容量 価格（税別） 在庫状況 数量
500 mg $25 在庫あり
1 g $40 在庫あり
5 g $80 在庫あり
10 g $128 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Poloxamer 188 関連抗体

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製品説明

Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery[1][2][3][4].

体外実験

Poloxamer 188 (10-1000 μM, 5 h) has a protective effect on cerebral microvascular endothelial cells (MBEC) in mice[2].
Docetaxel-loaded PLGA/poloxamer 188 nanoparticles leads to an increased level of drug uptake and cytotoxicity in the docetaxel-resistant MCF-7 TAX30 human breast cancer cells against Docetaxel-loaded PLGA nanoparticles[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Poloxamer 188 関連抗体

Cell Viability Assay [2]

Cell Line: MBEC
Concentration: 10, 100, 1000 μM
Incubation Time: 5 h
Result: Increased the cell number of hypoxic cells at high concentrations.
体内実験

Poloxamer 188 (150 mg/kg intravenously, 240 minutes apart) significantly reduces ischemia-reperfuse-associated muscular edema and lipid peroxidation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TourniquetInduced Ischemia-Reperfusion Injury in Rats[3]
Dosage: 150 mg/kg
Administration: i.v
Result: Reduced the elevated TBARS but not to control levels and SOD activity was at control levels.
臨床実験
分子量

8800(Average)

CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

COA (245 KB)

取扱説明書 (2659 KB)
参考文献
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Poloxamer 188 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poloxamer 1889003-11-6PEG-PPG-PEG, 8800 (Average Mn)Poloxamer188Poloxamer-188Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental ContaminantsSurfactantAnti-inflammatoryAntioxidantMBECTBARSInhibitorinhibitorinhibit

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Poloxamer 188
製品番号:
HY-D1005A
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