Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor  (Synonyms: PEGDA (MW 4000), MEHQ as inhibitor)

Poly(ethylene glycol) diacrylate (PEGDA) (MW 4000), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used to construct enzyme-responsive hydrogel drug delivery system^[1][2].

Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor is used to develop an intelligent drug delivery system that can be activated by the overexpressed matrix metalloproteinases (MMP-2/MMP-9) in the tumor microenvironment. Its large mesh structure ensures that MMPs can diffuse into the gel interior, cut the peptide chains, and achieve the enzymatic-responsive accelerated release of the drug ^[2].

Product Properties:
This product is readily soluble in water and can be prepared into hydrogel precursor solutions of varying concentrations. Adding the photoinitiator LAP (HY-44076) to this precursor solution triggers crosslinking upon illumination, yielding a hydrogel with a certain mechanical strength.
Instructions:
1. Dissolve this product at a concentration of 10-20 (w/w)% in pure water or phosphate buffer at room temperature, depending on the intended use. Add 0.1-0.3% (w/w)% LAP photoinitiator to prepare a gel precursor solution.
2. Add the above solution to the mold and refrigerate. Irradiation under 405 nm light for 30-60 seconds will form PEGDA hydrogel.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4000 (Average)

C₈H₁₀O₄

26570-48-9

Solid

White to off-white

O=C(C=C)OCCOC(C=C)=O.[n]

Room temperature in continental US; may vary elsewhere.

• [1]. Haiqing Lin, et al. The Effect of Cross-Linking on Gas Permeability in Cross-Linked Poly(Ethylene Glycol Diacrylate). Macromolecules 2005, 38, 20, 8381-8393.

  [2]. Tauro JR, Gemeinhart RA. Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes. Bioconjug Chem. 2005 Sep-Oct;16(5):1133-9.  [Content Brief]