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  4. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340

Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340  (Synonyms: Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340)

Cat. No.: HY-Y0332L
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Potassium dihydrogen phosphate (Potassium phosphate monobasic), meeting the analytical specifications of Ph. Eur., NF, E340, is a reagent with buffering capacity, used for preparing biological buffers. Potassium dihydrogen phosphate downregulates the expression of IκBα in the cytoplasm, increases the expression of p-P65 in the cytoplasm, and upregulates the expression of P65 in the nucleus, thereby activating the NF-κB pathway. Potassium dihydrogen phosphate promotes the proliferation of human periodontal ligament stem cells in the logarithmic growth phase. Potassium dihydrogen phosphate upregulates the expression of odontogenic/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) in human periodontal ligament stem cells and enhances the mineralization capacity of these cells. Potassium dihydrogen phosphate can be used in the research of periodontal diseases.

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Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340

Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Chemical Structure

CAS No. : 7778-77-0

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Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Related Antibodies

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Description

Potassium dihydrogen phosphate (Potassium phosphate monobasic), meeting the analytical specifications of Ph. Eur., NF, E340, is a reagent with buffering capacity, used for preparing biological buffers. Potassium dihydrogen phosphate downregulates the expression of IκBα in the cytoplasm, increases the expression of p-P65 in the cytoplasm, and upregulates the expression of P65 in the nucleus, thereby activating the NF-κB pathway. Potassium dihydrogen phosphate promotes the proliferation of human periodontal ligament stem cells in the logarithmic growth phase. Potassium dihydrogen phosphate upregulates the expression of odontogenic/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) in human periodontal ligament stem cells and enhances the mineralization capacity of these cells. Potassium dihydrogen phosphate can be used in the research of periodontal diseases[1].

In Vitro

Potassium dihydrogen phosphate (0.18-180 mM; 3 h) induces the highest ALP activity and protein expression in hPDLSCs at 1.8 mM[1].
Potassium dihydrogen phosphate (1.8 mM; 1-9 days) promotes the proliferation of PDLSCs in logarithmic growth phase without affecting cell apoptosis[1].
Potassium dihydrogen phosphate (1.8 mM; 3-14 days) enhances dentin/osteogenic differentiation and mineralization capacity of periodontal ligament stem cells (PDLSCs) by upregulating dentin/osteogenic marker genes and proteins[1].
Potassium dihydrogen phosphate (1.8 mM; 0-120 min) activates the NF-κB pathway in PDLSCs by downregulating cytoplasmic IκBα, upregulating cytoplasmic p-P65, and promoting the nuclear translocation of P65[1].
The enhanced odontogenic/osteogenic differentiation of periodontal ligament stem cells (PDLSCs) induced by potassium dihydrogen phosphate (1.8 mM; 30-60 min, combined with BMS345541 for 14 days) can be attenuated by BMS345541 (HY-10519) via inhibition of the NF-κB pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human periodontal ligament stem cells (PDLSCs)
Concentration: 1.8 mmol/L
Incubation Time: 0, 1, 3, 5, 7, and 9 days
Result: Promoted PDLSC proliferation in the logarithmic growth phase.
Showed no significant difference in cell apoptosis compared to the control group.

Western Blot Analysis[1]

Cell Line: human periodontal ligament stem cells (PDLSCs)
Concentration: 1.8 mmol/L
Incubation Time: 0, 15, 30, 60, 120 min
Result: Down-regulated cytoplasmic IκBα expression.
Up-regulated cytoplasmic p-P65 expression, which reached a maximum.
Significantly up-regulated nuclear P65 expression.
Molecular Weight

136.09

Formula

H2KO4P
CAS No.
SMILES

O=P(O[O])=O.[KH2]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E3407778-77-0Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340Biochemical Assay ReagentsNF-κBNuclear factor-κBNuclear factor-kappaBbuffering capacity reagentP65odonto/osteogenic markersp-P65DSP/DSPPIκBαPDLSCsOCNhPDLSCshuman periodontal ligament stem cellsNF-κB pathwayperiodontal diseasesInhibitorinhibitorinhibit

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