Potassium dihydrogen phosphate, AR,99.5%
Based on 1 Customer Validation
Potassium dihydrogen phosphate, AR,99.5% is a potassium salt. Potassium dihydrogen phosphate, AR,99.5% activates NF-κB. Potassium dihydrogen phosphate, AR,99.5% upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, AR,99.5% promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, AR,99.5% promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, AR,99.5% is applicable to periodontal disease-related research.
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- Assay : 99.7%
- No. CAS: 7778-77-0
- Fòrmula: KH2PO4
- Peso molecular:136.08
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Almacenamiento:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-W019883
Dipotassium hydrogen phosphatePharmaceutical Excipient -
HY-Y0537
Potassium chloride, AR, 99.5%Potassium Supplement -
HY-D0857
HEPESZwitterionic Buffer -
HY-Y0537E
Potassium chloride, for cell cultureInorganic Salt -
HY-D0227
THAMBiochemical Assay Reagents -
HY-B2243D
Anhydrous sodium dihydrogen phosphate, for cell cultureAnhydrous sodium dihydrogen phosphate, Cell level -
HY-Y0308E
Sodium phosphate dibasic, for cell cultureBuffer -
HY-Y0332K
Potassium dihydrogen phosphate, for cell cultureCell Culture Reagent -
HY-Y0344D
Sodium chloride, for cell cultureBiochemical Assay Reagent -
HY-W019981C
Magnesium chloride hexahydrate, for cell cultureMagnesium Ion Source -
HY-15921
IPTGAllolactose Mimic -
HY-Y0261A
Ammonium sulphate,≥99.0%,ARBiochemical Assay Reagent
Actividad biológica
Descripciòn
IC50 & Target
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RUNX2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
39 μM
Compound: 516951
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Substrate uptake by the Sodium-Dependent Phosphate Transport Protein 2A (NPT2a, SLC34A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC34A1 cells
Substrate uptake by the Sodium-Dependent Phosphate Transport Protein 2A (NPT2a, SLC34A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC34A1 cells
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10.5281/zenodo.7355196 |
In Vitro
Potassium dihydrogen phosphate (1.8 mmol/L; treated on days 0, 1, 3, 5, 7, and 9) promotes the proliferation of PDLSCs in the logarithmic growth phase[1].
Potassium dihydrogen phosphate (1.8 mmol/L; 3 or 7 days) exerts no significant effect on the apoptosis rate of PDLSCs[1].
Potassium dihydrogen phosphate (1.8 mmol/L; 3 or 7 days) upregulates dentin/osteogenesis-related proteins in PDLSCs[1].
Potassium dihydrogen phosphate (180 mg/L) significantly promotes the growth of somatic embryo explants of *Dendrobium* 'Sonia' in MS medium. After 3 months of culture, each explant produces an average of 4.41 leaves with a leaf length of 1.16 cm, and the fresh weight of the tissue-cultured seedlings reaches 0.10 g[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human periodontal ligament stem cells (PDLSCs)
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Concentration:1.8 mmol/L
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Incubation Time:3 d, 7 d
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Result:Increased the expression of odonto/osteogenic proteins (OCN, DSP, OSX, RUNX2, ALP) at day 3 and 7 compared to control (P < 0.05, P < 0.01).
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Cell Line:human periodontal ligament stem cells (PDLSCs)
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Concentration:1.8 mmol/L
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Incubation Time:3 d, 7 d
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Result:Increased the expression of odonto/osteogenic genes (OCN, DSP, OSX, RUNX2, ALP) at day 3 and 7 compared to control (P < 0.05, P < 0.01).
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Cell Line:human periodontal ligament stem cells (PDLSCs)
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Concentration:1.8 mmol/L
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Incubation Time:15 min, 30 min, 60 min, 120 min
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Result:Down-regulated IκBα expression, reaching minimum at 30 min (P < 0.01).
Up-regulated nuclear P65 expression at 60 min (P < 0.01).
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 7778-77-0
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Appearance Solid
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Peso molecular 136.08
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Fòrmula KH2PO4
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Color Colorless to off-white
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SMILES
O=P(O[O])=O.[KH2]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvente y solubilidad
In Vitro:
H2O : 50 mg/mL (367.43 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.3486 mL | 36.7431 mL | 73.4862 mL | 183.7155 mL |
| 5 mM | 1.4697 mL | 7.3486 mL | 14.6972 mL | 36.7431 mL | |
| 10 mM | 0.7349 mL | 3.6743 mL | 7.3486 mL | 18.3715 mL | |
| 15 mM | 0.4899 mL | 2.4495 mL | 4.8991 mL | 12.2477 mL | |
| 20 mM | 0.3674 mL | 1.8372 mL | 3.6743 mL | 9.1858 mL | |
| 25 mM | 0.2939 mL | 1.4697 mL | 2.9394 mL | 7.3486 mL | |
| 30 mM | 0.2450 mL | 1.2248 mL | 2.4495 mL | 6.1238 mL | |
| 40 mM | 0.1837 mL | 0.9186 mL | 1.8372 mL | 4.5929 mL | |
| 50 mM | 0.1470 mL | 0.7349 mL | 1.4697 mL | 3.6743 mL | |
| 60 mM | 0.1225 mL | 0.6124 mL | 1.2248 mL | 3.0619 mL | |
| 80 mM | 0.0919 mL | 0.4593 mL | 0.9186 mL | 2.2964 mL | |
| 100 mM | 0.0735 mL | 0.3674 mL | 0.7349 mL | 1.8372 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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