PPIase-Parvulin inhibitor 

PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC_50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs)^[1].

PPIase-Parvulin Inhibitor can inhibit the proliferation of wild-type MEFs (IC₅₀: ~1 μM), but its effect on Pin1^-/- MEFs is not significant^{[ 1 ]}.
The inhibitory potency (IC₅₀s) of PPIase-Parvulin Inhibitor against HCT116 and HSC2 cells was 1.2 μM and 0.7 μM^[1], respectively.
PPIase-Parvulin Inhibitor (1 μM; 48 h) can reduce the protein levels of cyclins D1 and B1 in HCT116 cells, but has no significant effect on cyclins E and A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

438.39

C₂₂H₁₈N₂O₈

64005-90-9

Solid

Off-white to light yellow

O=C(N(CC(OCC)=O)C1=O)C2=CC=C(C3=C4C=CC1=C23)C(N(CC(OCC)=O)C4=O)=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24.  [Content Brief]